Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E3A | used as reference mutation, similar activity as the wild-type enzyme, shows high resistance against malonyl-CoA | Homo sapiens |
E531K | naturally occuring mutation | Homo sapiens |
I66V | naturally occuring mutation | Homo sapiens |
I66V/E531K | naturally occuring mutation, activity is not markedly different from wild-type enzyme, sensitivity toward malonyl-CoA is not markedly different from the sensitivity of wild-type enzyme | Homo sapiens |
I66V/S427C | naturally occuring mutation, activity is not markedly different from wild-type enzyme, sensitivity toward malonyl-CoA is not markedly different from the sensitivity of wild-type enzyme | Homo sapiens |
L764R | used as reference mutation, negligible activity | Homo sapiens |
S427C | naturally occuring mutation, activity is not markedly different from wild-type enzyme, sensitivity toward malonyl-CoA is not markedly different from the sensitivity of wild-type enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
malonyl-CoA | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-carnitine + palmitoyl-CoA | - |
Homo sapiens | L-palmitoylcarnitine + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carnitine palmitoyltransferase I | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00003 | - |
- |
Homo sapiens | malonyl-CoA |