Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial matrix | - |
Homo sapiens | 5759 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
38000 | - |
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline | ping-pong reaction mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
liver | high content | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
trimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ornithine transcarbamoylase | - |
Homo sapiens |
OTC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inborn deficiency of OTC causes mainly urea cycle-related disorders and leads to hyperammonemic states that may become lethal. Some states of hepatotoxicity are associated woth hepatocyte disruption and release of OTC into the bloodstream | Homo sapiens |
physiological function | OTC is involved in the metabolic transformation of arginine and proline and participates in the urea cycle. OTC is regulated by glucocorticoids and other transcriptional factors, such as C/EFP and HNF-4. OTC is released into the blood stream from liver in case of liver regeneration cell proliferation, extracellular might play a role as signaling molecule | Homo sapiens |