Literature summary for 2.1.1.366 extracted from

Lee, S.; Lee, C.; Hwang, C.Y.; Kim, D.; Han, Y.; Hong, S.N.; Kim, S.H.; Cho, K.H.
Network inference analysis identifies SETDB1 as a key regulator for reverting colorectal cancer cells into differentiated normal-like cells (2020), Mol. Cancer Res., 18, 118-129 .

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Application

Application	Comment	Organism
medicine	SETDB1 depletion effectively converts stem-like colorectal cancer cells into postmitotic cells and restores normal morphology in patient-derived colorectal cancer organoids. SETDB1 depletion recapitulates global gene expression profiles of normal differentiated cells by restoring the transcriptional activity of core transcription factors such as CDX2, ELF3, HNF4G, PPARG, and VDR, on their target genes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q15047	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
SW-480 cell	-	Homo sapiens	-
SW-620 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)