Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86U44 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
methyltransferase-like 3 | - |
Homo sapiens |
METTL3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | hepatitis B X-interacting protein (HBXIP) up-regulates METTL3 by suppressing let-7g, in which METTL3 increases HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer. Expression of METTL3 is positively related to that of HBXIP in clinical breast cancer tissues | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme (METTL3) is involved in RNA metabolism through N6-methyladenosine modification. The oncoprotein HBXIP up-regulates METTL3 by inhibiting the expression of tumor suppressor let-7g in breast cancer. METTL3 increases the expression of HBXIP, forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP in breast cancer cells | Homo sapiens |