Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9D6Y7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase A | - |
Mus musculus |
MsrA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | MsrA deficiency increases both basal and acetaminophen-induced thioredoxin reductase 1 expression levels, likely through increased Nrf2 activation. Conversely, MsrA overexpression diminishes the augmented thioredoxin reductase 1 levels in acetaminophen-treated MsrA(-/-) hepatocytes, reducing susceptibility against acetaminophen-induced cytotoxicity | Mus musculus |
physiological function | the enzyme protects hepatocytes against acetaminophen-induced toxicity via regulation of thioredoxin reductase 1 expression | Mus musculus |