Literature summary for 1.5.3.17 extracted from

Lane, D.J.R.; Bae, D.H.; Siafakas, A.R.; Suryo Rahmanto, Y.; Al-Akra, L.; Jansson, P.J.; Casero, R.A.; Richardson, D.R.
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes (2018), Biochim. Biophys. Acta Mol. Basis Dis., 1864, 2793-2813 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-
HaCaT cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
SK-MEL-28 cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	cellular iron levels robustly regulate 13 polyamine pathway proteins. Four proteins are down-regulated (i.e., acireductone dioxygenase 1, methionine adenosyltransferase 2alpha, antizyme and polyamine oxidase) and three proteins are up-regulated (i.e., S-adenosyl methionine decarboxylase, antizyme inhibitor 1 and spermidine/spermine-N1-acetyltransferase 1). Depletion of iron also markedly decreases polyamine pools, (i.e., spermidine and/or spermine, but not putrescine)	down

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Release 2023.1 (January 2023)