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Literature summary for 1.5.1.3 extracted from
- Cryo-kinetics reveal dynamic effects on the chemistry of human dihydrofolate reductase (2021), ChemBioChem, 22, 2410-2414 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P00374 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,8-dihydrofolate + NADPH + H+ | - |
Homo sapiens | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | enzyme displays a kinetic isotope effect KIE (kHLE/kHHE) close to unity above 0°C. The enzyme KIE is increased to 1.720 at -20°C, The coupling of protein motions to the chemical step may be minimized under optimal conditions but enhanced at non-physiological temperatures | Homo sapiens |
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Release 2023.1 (January 2023)
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