Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | kinetic mechanism | Escherichia coli | |
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ | rapid random equilibrium mechanism with NADPH and reduced acetylpyridine adenine nucleotide as cofactor | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + acetylpyridine adenine nucleotide, reduced | - |
Escherichia coli | 5,6,7,8-tetrahydrofolate + acetylpyridine adenine nucleotide, oxidized | - |
? | |
additional information | 3-acetylpyridine adenine dinucleotide + dihydrofolate: rapid equilibrium random mechanism | Escherichia coli | ? | - |
? | |
additional information | NADPH + dihydrofolate: steady-state random mechanism | Escherichia coli | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
7,8-dihydrofolate | with acetylpyridine adenine nucleotide | Escherichia coli | |
2 | - |
acetylpyridine adenine nucleotide | with 7,8-dihydrofolate | Escherichia coli | |
11 | - |
NADPH | with 7,8-dihydrofolate | Escherichia coli | |
18 | - |
7,8-dihydrofolate | with NADPH | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
3-acetylpyridine adenine nucleotide | - |
Escherichia coli | |
NADPH | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Ki of substrates dihydrofolate, NADPH and acetylpyridine adenine nucleotide | Escherichia coli |