Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
dentate gyrus | - |
Rattus norvegicus | - |
granule cell | - |
Rattus norvegicus | - |
hippocampus | PNPO immunoreactivities are significantly increased in the rat hippocampus accompanied by reductions in paired-pulse inhibition at 1 day and 1 week after status epilepticus | Rattus norvegicus | - |
additional information | immunohistochemic analysis, overview | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
pyramidal cell | Cornu Ammonis 1 pyramidal cells | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
PNPO | - |
Rattus norvegicus |
pyridoxal 5'-phosphate synthetic enzyme | - |
Rattus norvegicus |
pyridoxine-5'-phosphate oxidase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | PNPO immunoreactivities are significantly increased in the rat hippocampus accompanied by reductions in paired-pulse inhibition at 1 day and 1 week after status epilepticus | up |
General Information | Comment | Organism |
---|---|---|
additional information | neurological diseases lead to upregulation of PNPO, immunoreactivities are mainly increased in glutamatergic principal neurons, dentate granule cells and CA1 pyramidal cells, and astrocytes independently of 4-aminobutyric acid levels, overview | Rattus norvegicus |
physiological function | upregulation of PNPO expression may be involved in dendritic spine reorganization, which in turn, promotes the reverberation of recurrent excitatory networks in the hippocampus following status epilepticus. Activity-dependent regulation of PLP synthetic enzyme levels may play a role in tissue excitability in the hippocampus via various pathways | Rattus norvegicus |