Literature summary for 1.4.3.14 extracted from

Lukasheva, E.V.; Makletsova, M.G.; Lukashev, A.N.; Babayeva, G.; Arinbasarova, A.Y.; Medentsev, A.G.
Fungal enzyme L-lysine alpha-oxidase affects the amino acid metabolism in the brain and decreases the polyamine level (2020), Pharmaceuticals, 13, 398 .

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Application

Application	Comment	Organism
medicine	the enzyme may be used to reduce levels of L-Lys and polyamines in the brain. The enzyme enetrates into the brain and is retained there for up to 48 h after intravenous injection. The most significant impact of the enzyme is towards amino acids, which are directly exposed to its action (L-Lys, L-Orn, L-Arg). In addition, the enzyme significantly affects the redistribution of amino acids directly associated with the tricarboxylic acid cycle (L-Asp and l-Glu). The depletion of L-Orn, the precursor of polyamines, leads to a significant and long-term decrease in the concentration of polyamines, which are responsible for regulation of many processes including cell proliferation	Trichoderma aureoviride

Organism

Organism	UniProt	Comment	Textmining
Trichoderma aureoviride	-	-	-
Trichoderma aureoviride Rifai VKM F-4268D	-	-	-

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Release 2023.1 (January 2023)