Literature summary for 1.4.3.1 extracted from

Rabattoni, V.; Pollegioni, L.; Tedeschi, G.; Maffioli, E.; Sacchi, S.
Cellular studies of the two main isoforms of human D-aspartate oxidase (2021), FEBS J., 288, 4939-4954 .

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Application

Application	Comment	Organism
medicine	the additional N-terminal peptide present in the DASPO_369 splicing isoform only has been identified in hippocampus of Alzheimer's disease female patients, while peptides corresponding to the remaining part of the protein are present in samples from male and female healthy controls and Alzheimer's disease patients. Upon expression in U87 human glioblastoma cells, the DASPO_369 protein shows a lower expression compared with the canonical isoform. Both protein isoforms are active, localize to the peroxisomes, are very stable, and are primarily degraded through the ubiquitin-proteasome system	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99489	the human DDO gene produces alternative transcripts encoding for three putative DASPO isoforms, constituted by 341 (the canonical form), 369, and 282 amino acids	-

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Release 2023.1 (January 2023)