Application | Comment | Organism |
---|---|---|
medicine | development of small molecule inhibitors against DHODH | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with low molecular weight compounds that inhibit the enzyme in the nanomolar range, by hanging-drop vapor diffusion method, to 2.15 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | competitive nature of small molecule inhibitors toward the putative ubiquinone binding site | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02127 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroorotate + 2,6-dichlorophenolindophenol | - |
Homo sapiens | orotate + reduced 2,6-dichlorophenolindophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHODH | - |
Homo sapiens |