Application | Comment | Organism |
---|---|---|
medicine | enzyme inhibition is a mechanism of action that may be relevant for the therapeutic effects of leflunomide | Homo sapiens |
medicine | great interest in inhibitors as potential therapeutic agents for the treatment of diseases involving aberrant cell proliferation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide | anti-proliferative effect of A77 1726 is mediated by inhibition of enzyme | Homo sapiens | |
A77 1726 | active metabolite of leflunomide | Homo sapiens | |
brequinar sodium | more active than A77 1726 and HR325 | Homo sapiens | |
HR325 | structural analogue of A77 1726 | Homo sapiens | |
leflunomide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43000 | - |
x * 43000, SDS-PAGE | Homo sapiens |
43000 | - |
? * 43000 | Homo sapiens |
130000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
U937 membranes | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
ion-exchange, hydroxyapatite, gel filtration for U937, cation-exchange for spleen | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spleen | - |
Homo sapiens | - |
U-937 cell | promyelomonocytic, histiocytic | Homo sapiens | - |
Storage Stability | Organism |
---|---|
-80°C | Homo sapiens |
Subunits | Comment | Organism |
---|---|---|
? | x * 43000, SDS-PAGE | Homo sapiens |
? | ? * 43000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DHO-DH | - |
Homo sapiens |