Literature summary for 1.2.4.2 extracted from

Burch, J.S.; Marcero, J.R.; Maschek, J.A.; Cox, J.E.; Jackson, L.K.; Medlock, A.E.; Phillips, J.D.; Dailey, H.A.
Glutamine via alpha-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis (2018), Blood, 132, 987-998 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	Q60597	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
culture condition:CD34+ cell	-	Homo sapiens	-
erythrocyte	-	Mus musculus	-
hematopoietic stem cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
KDH	alpha-ketoglutarate dehydrogenase is composed of 3 subunits: oxoglutarate dehydrogenase (E1), dihydrolipoamide S-succinyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)	Homo sapiens
Kdh E1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	during late stages of erythropoiesis, cellular metabolism is remodeled so that glutamine is the precursor for 5-aminolevulinate following deamination to 2-oxoglutarate and conversion to succinyl-CoA by 2-oxoglutarate dehydrogenase without equilibration or passage through the TCA cycle. This may be facilitated by a direct interaction between 5-aminolevulinate synthase 2 and 2-oxoglutarate dehydrogenase. Succinate is not an effective precursor for heme	Mus musculus

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Release 2023.1 (January 2023)