Literature summary for 1.2.4.1 extracted from

Yang, M.; Zhang, X.
Construction of pyruvate producing strain with intact pyruvate dehydrogenase and genome-wide transcription analysis (2017), World J. Microbiol. Biotechnol., 33, 59 .

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Application

Application	Comment	Organism
synthesis	production of pyruvate in an Escherichia coli strain with central metabolic pathways modified. Genes ldhA, pflB, pta-ackA, poxB, ppc, frdBC are knocked out sequentially and full pyruvate dehydrogenase is retained. In batch fermentation with M9 medium, pyruvate yield and production rate reach 0.63 g/g glucose and 1.89 g/(1 h), respectively. The production of acetate, succinate, and other carboxylates is effectively controlled, while the pathways of convertion of pyruvate to phosphoenol pyruvate and acetyl CoA are enhanced	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0AFG8	-	-
Escherichia coli MG1655	P0AFG8	-	-

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Release 2023.1 (January 2023)