Protein Variants | Comment | Organism |
---|---|---|
additional information | hyaluronan levels are increased in the bronchoalveolar lavage fluid after asbestos-induced pulmonary injury, and this response is markedly enhanced in EC-SOD knock-out mice, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | EC-SOD protects the lung in both bleomycin- and asbestos-induced models of pulmonary fibrosis | ? | - |
? | |
O2.- + H+ | Homo sapiens | EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments, thereby preventing activation of polymorphic neutrophil chemotaxis by fragmented hyaluronic acid, overview | O2 + H2O2 | - |
? | |
O2.- + H+ | Mus musculus | EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid via its matrix-binding domain and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments | O2 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
male C57BL/6 mice | - |
Purification (Comment) | Organism |
---|---|
EC-SOD from aorta | Homo sapiens |
native EC-SOD from mouse lungs by hyaluronic acid affinity chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | high expression level of EC-SOD | Mus musculus | - |
lung | high expression level of EC-SOD | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | EC-SOD protects the lung in both bleomycin- and asbestos-induced models of pulmonary fibrosis | Homo sapiens | ? | - |
? | |
O2.- + H+ | - |
Mus musculus | O2 + H2O2 | - |
? | |
O2.- + H+ | - |
Homo sapiens | O2 + H2O2 | - |
? | |
O2.- + H+ | EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments, thereby preventing activation of polymorphic neutrophil chemotaxis by fragmented hyaluronic acid, overview | Homo sapiens | O2 + H2O2 | - |
? | |
O2.- + H+ | EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid via its matrix-binding domain and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments | Mus musculus | O2 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EC-SOD | - |
Mus musculus |
EC-SOD | - |
Homo sapiens |
extracellular superoxide dismutase | - |
Mus musculus |
extracellular superoxide dismutase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |