Application | Comment | Organism |
---|---|---|
medicine | enzyme catalyzes the production of 9alpha-hydroxy-4-androstene-3,17-dione, an important intermediate for the semi-synthesis of potent anti-inflammatory drugs such as 9alpha-fluorocorticoids from 4-androstene-3,17-dione | Mycolicibacterium fortuitum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.068 | - |
NADH | - |
Mycolicibacterium fortuitum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Nocardia sp. | 5829 | - |
cytosol | - |
Mycolicibacterium fortuitum | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Nocardia sp. | |
Fe2+ | iron-sulfur group | Mycolicibacterium fortuitum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
NADH reductase component, SDS-PAGE | Mycolicibacterium fortuitum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Nocardia sp. | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Mycolicibacterium fortuitum | - |
9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycolicibacterium fortuitum | - |
KCTC 1122, ATCC 6842 | - |
Nocardia sp. | - |
- |
- |
Purification (Comment) | Organism |
---|---|
NADH reductase component | Mycolicibacterium fortuitum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
6.18 | - |
NADH reductase component | Mycolicibacterium fortuitum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Nocardia sp. | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Mycolicibacterium fortuitum | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Nocardia sp. | |
FAD | - |
Mycolicibacterium fortuitum | |
NADH | - |
Nocardia sp. | |
NADH | - |
Mycolicibacterium fortuitum |