Application | Comment | Organism |
---|---|---|
medicine | manipulation of hormone signaling pathways can provide a strategy to enhance Cyp7a1 activity in human patients | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene Cyp7a1, enzyme expression analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22680 | gene CYP7A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7 alpha-hydroxylase | - |
Homo sapiens |
CYP7A1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Cyp7a1 is a direct thyroid hormone target gene that responds to physiologic thyroid hormone levels through a set of distinct response elements in its promoter | up |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the cytochrome P450 family | Homo sapiens |
additional information | thyroid hormones regulate cholesterol to bile acid conversion in similar ways in humans and rodent experimental models | Homo sapiens |
physiological function | thyroid hormone modulates serum cholesterol by acting on thyroid hormone receptor beta1 in liver to regulate metabolic gene sets. One important thyroid hormone regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and plays a crucial role in regulation of serum cholesterol levels | Homo sapiens |