Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22680 | gene CYP7A1 | - |
Mus musculus | Q64505 | gene CYP7A1 | - |
Mus musculus C57BL/6 | Q64505 | gene CYP7A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | enzyme expression analysis, increased levels of Cyp7a1/CYP7A1 mRNA in human hepatocytes treated with 1alpha,25-dihydroxyvitamin D3 | Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
hepatocyte | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | distribution of vitamin D receptor and enzyme proteins in the liver by immunostaining, overview | Mus musculus | - |
additional information | enzyme expression analysis in mice fed normal or Western diets for 3 weeks and then given intraperitoneal injections of vehicle (corn oil) or 1alpha,25-dihydroxyvitamin D3 in 4 doses of 0.0025 mg/kg, every other day. Increased levels of Cyp7a1/CYP7A1 mRNA in mouse hepatocytes treated with 1alpha,25-dihydroxyvitamin D3 | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7alpha-hydroxylase | - |
Homo sapiens |
cholesterol 7alpha-hydroxylase | - |
Mus musculus |
CYP7A1 | - |
Homo sapiens |
CYP7A1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in farnesoid X receptor-deficient and wild-type mice with hypercholesterolemia, injection of 1alpha,25-dihydroxyvitamin D3 consistently reduces levels of plasma and liver cholesterol and farnesoid X receptor small heterodimer partner Shp mRNA, and increases hepatic Cyp7a1 mRNA and protein. The transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), are essential for CYP7A1 expression | up |
Mus musculus | in farnesoid X receptor-deficient and wild-type mice with hypercholesterolemia, injection of 1alpha,25-dihydroxyvitamin D3 consistently reduces levels of plasma and liver cholesterol and farnesoid X receptor small heterodimer partner, Shp, mRNA, and increases hepatic Cyp7a1 mRNA and protein. The transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), are essential for CYP7A1 expression | up |
General Information | Comment | Organism |
---|---|---|
metabolism | bile acids such as chenodeoxycholic acid (CDCA) activate farnesoid X receptor FXR to increase transcription of small heterodimer partner SHP, an atypical nuclear receptor that lacks a DNA binding domain and represses CYP7A1 activation by suppression of transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), which are essential for CYP7A1 expression. A second negative feedback mechanism on CYP7A1 is found in the intestine, where activation of FXR induces fibroblast growth factor 15/19, a hormonal signaling molecule that represses CYP7A1 through interaction with the liver fibroblast growth factor receptor 4 via the c-Jun signaling pathway. Role for the vitamin D receptor on CYP7A1 regulation, overview | Homo sapiens |
metabolism | bile acids such as chenodeoxycholic acid (CDCA) activate farnesoid X receptor FXR to increase transcription of small heterodimer partner SHP, an atypical nuclear receptor that lacks a DNA binding domain and represses CYP7A1 activation by suppression of transcription factors, liver receptor homolog-1 (NR5A2) and hepatocyte nuclear factor 4a (NR2A1), which are essential for CYP7A1 expression. A second negative feedback mechanism on CYP7A1 is found in the intestine, where activation of FXR induces fibroblast growth factor 15/19, a hormonal signaling molecule that represses CYP7A1 through interaction with the liver fibroblast growth factor receptor 4 via the c-Jun signaling pathway. Role for the vitamin D receptor on CYP7A1 regulation, overview | Mus musculus |
additional information | activation of the vitamin D receptor represses hepatic SHP to increase levels of human CYP7A1 and reduce cholesterol | Homo sapiens |
additional information | in farnesoid X receptor-deficient and wild-type mice with hypercholesterolemia, injection of 1alpha,25-dihydroxyvitamin D3 consistently reduces levels of plasma and liver cholesterol and farnesoid X receptor small heterodimer partner Shp mRNA, and increases hepatic Cyp7a1 mRNA and protein. Activation of the vitamin D receptor represses hepatic SHP to increase levels of mouse CYP7A1 and reduce cholesterol | Mus musculus |