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Literature summary for 1.14.11.53 extracted from

  • Selberg, S.; Seli, N.; Kankuri, E.; Karelson, M.
    Rational design of novel anticancer small-molecule RNA m6A demethylase ALKBH5 inhibitors (2021), ACS Omega, 6, 13310-13320 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.53

Inhibitors

Inhibitors Comment Organism Structure
2-[(1-hydroxy-2-oxo-2-phenylethyl)sulfanyl]acetic acid cell proliferation of cell lines HL-60, CCRF-CEM, and K562 is suppressed at low micromolar concentrations. The effect is low or negligible in Jurkat cells and glioblastoma cell line A-172 Homo sapiens
4-[[(furan-2-yl)methyl]amino]-1,2-diazinane-3,6-dione cell proliferation of cell lines HL-60, CCRF-CEM, and K562 is suppressed at low micromolar concentrations. The effect is low or negligible in Jurkat cells and glioblastoma cell line A-172 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6P6C2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCRF-CEM cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00084
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-[(1-hydroxy-2-oxo-2-phenylethyl)sulfanyl]acetic acid
0.00179
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-[[(furan-2-yl)methyl]amino]-1,2-diazinane-3,6-dione