Application | Comment | Organism |
---|---|---|
diagnostics | the prolyl-4-hydroxylase alpha subunit 2 is a biomarker for breast cancer progression. Increased mRNA levels of P4HA2 correlate with poor clinical outcome in breast cancer patients, which is independent of estrogen receptor status | Homo sapiens |
medicine | the prolyl-4-hydroxylase alpha subunit 2 is a potential therapeutic target for the disorders associated with increased collagen deposition and a biomarker for breast cancer progression | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene P4HA2, enzyme expression analysis, P4HA2 is associated with expression of Col1A1, Col3A1, and Col4A1 during breast cancer development and progression | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | recombinant expression of sh-P4HA2-1 and sh-P4HA2-2 in breast cancer cell lines HMT-3522 T4-2, MDA-MB-231, ZR-75-1, and MDA-MB-157 for gene silencing, phenotypes, detailed overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-dihydrophenanthrolin-4-one-3-carboxylic acid | 1,4,DPCA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | - |
Homo sapiens | 31012 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-proline + 2-oxoglutarate + O2 | Homo sapiens | - |
procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15460 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
breast cancer cell | P4HA2 mRNA levels are significantly upregulated in breast cancer compared to normal mammary tissue | Homo sapiens | - |
HMT-3522 T4-2 cell | - |
Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
MDA-MB-157 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
ZR-75-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | procollagen trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
collagen prolyl-4-hydroxylase alpha subunit 2 | - |
Homo sapiens |
P4ha2 | - |
Homo sapiens |
prolyl-4-hydroxylase alpha subunit 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing P4HA2 expression or treatment with a P4HA inhibitor significantly inhibits cell proliferation and suppresses aggressive phenotypes of breast cancer cells in 3D culture, accompanied by reduced deposition of collagen I and IV. Knockdown of P4HA2 inhibits mammary tumor growth and metastasis to lungs in xenograft models. Increased mRNA levels of P4HA2 correlate with poor clinical outcome in breast cancer patients, which is independent of estrogen receptor status. Kaplan-Meier survival analysis, overview | Homo sapiens |
physiological function | collagen prolyl-4-hydroxylase alpha subunit 2 (P4HA2) hydroxylates proline residues in -X-Pro-Gly- sequences. Expression and function of P4HA2 in breast cancer progression, P4HA2 is associated with expression of Col1A1, Col3A1, and Col4A1 during breast cancer development and progression | Homo sapiens |