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Literature summary for 1.13.11.58 extracted from

  • ElBordiny, H.S.; El-Miligy, M.M.; Kassab, S.E.; Daabees, H.; Mohamed Ali, W.A.; Abdelhamid Mohamed El-Hawash, S.
    Design, synthesis, biological evaluation and docking studies of new 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives as potent antioxidants and 15-lipoxygenase inhibitors (2018), Eur. J. Med. Chem., 145, 594-605 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1-[5-(2-phenyl-1H-indol-3-yl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one
-
 Glycine max
2-phenyl-3-[3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-1H-indole most potent inhibitor tested Glycine max
2-phenyl-3-[3-(pyridin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]-1H-indole
-
 Glycine max

Organism

Organism UniProt Comment Textmining
Glycine max P09186
-
-

Synonyms

Synonyms Comment Organism
15-LOX
-
 Glycine max
LOX1.3
-
 Glycine max

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00384
-
 pH not specified in the publication, temperature not specified in the publication Glycine max 2-phenyl-3-[3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-5-yl]-1H-indole
0.00456
-
 pH not specified in the publication, temperature not specified in the publication Glycine max 1-[5-(2-phenyl-1H-indol-3-yl)-3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one
0.00489
-
 pH not specified in the publication, temperature not specified in the publication Glycine max 2-phenyl-3-[3-(pyridin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]-1H-indole