Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | a quintet state of the 2,3-dihydroxybiphenyl-iron-dioxygen group adducts is the reactive state with a substrate character. The HOO radical species is the reactive oxygen species responsible for the subsequent attack of 2,3-dihydroxybiphenyl | Pseudomonas sp. KKS102 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas sp. KKS102 | P17297 | - |
- |
General Information | Comment | Organism |
---|---|---|
metabolism | tThe HOO radical species is the reactive oxygen species responsible for the attack of 2,3-dihydroxybiphenyl. The first step in proton-coupled electron transfer is the rate-determining step with a potential energy barrier of 17.2 kcal/mol, close to the experimental value of 14.7 kcal/mol. Residue His194 acts as an acid-base catalyst to deprotonate the hydroxyl group of 2,3-dihydroxybiphenyl at an early stage, then stabilizes the negative charge on the dioxygen group, and finally promotes the semialdehyde product formation as a proton donor | Pseudomonas sp. KKS102 |