Application | Comment | Organism |
---|---|---|
medicine | activity of 12S-lipoxygenase is hardly observed in liver cytosol of normal chow-fed mice but is clearly detectable in that of nonalcoholic steatohepatitis model mice prepared by feeding a methionine and choline-deficient diet | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P39655 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | activity of 12S-lipoxygenase is hardly observed in liver cytosol of normal chow-fed mice but is clearly detectable in that of nonalcoholic steatohepatitis model mice prepared. The expression levels of mRNA and protein of platelet-type 12S-lipoxygenase in the liver of methionine- and choline-deficient diet-fed mice are significantly increased compared with those of normal chow-fed mice. Platelet-type 12S-lipoxygenase colocalizes with alpha-smooth muscle actin as well as vitamin A in the cells distributing along liver sinusoids | Mus musculus |