Inhibitors | Comment | Organism | Structure |
---|---|---|---|
baicalein | 12-LOX inhibition attenuates platelet aggregation | Homo sapiens | |
NCTT-956 | 12-LOX inhibition attenuates platelet aggregation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
12-LOX | - |
Mus musculus |
12-LOX | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | 12-LOX inhibition attenuates platelet aggregation | Homo sapiens |
malfunction | the time to cessation of bleeding in 12-LOX-/- mice is significantly prolonged. Mice deficient in 12-LOX show a significant attenuation of alphaIIbeta3 activation for both agonists compared to wild-type mice | Mus musculus |
physiological function | inhibition of 12-LOX activity inhibits platelet aggregation, which is coupled to a significant shift in the ability of the platelet to induce normal integrin activation, dense granule secretion, and platelet adhesion under venous shear | Homo sapiens |