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Literature summary for 1.13.11.20 extracted from

  • Zhao, J.; Han, Y.; Ma, X.; Zhou, Y.; Yuan, S.; Shen, Q.; Ye, G.; Liu, H.; Fu, P.; Zhang, G.; Qiao, B.; Liu, A.
    Cysteine dioxygenase regulates the epithelial morphogenesis of mammary gland via cysteine sulfinic acid (2019), iScience, 13, 173-189 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus P60334
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium
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 Mus musculus
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mammary gland
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 Mus musculus
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General Information

General Information Comment Organism
physiological function CDO knockout female mice exhibit severe defects in mammary branching morphogenesis and ductal elongation, resulting in poor lactation. CDO contributes to the luminal epithelial cell differentiation, proliferation, and apoptosis mainly through its downstream product cysteine sulfinic acid. Exogenous supplementation of cysteine sulfinic acid rescues the defects in CDO knockout mice and enhances ductal growth in wild-type mice Mus musculus