Literature summary for 1.13.11.20 extracted from

Kang, Y.P.; Torrente, L.; Falzone, A.; Elkins, C.M.; Liu, M.; Asara, J.M.; Dibble, C.C.; DeNicola, G.
Correction Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer (2019), eLife, 8, e45572 .

Search for more literature for 1.13.11.20

Application

Application	Comment	Organism
medicine	CDO1 is preferentially silenced by promoter methylation in human non-small cell lung cancers harboring mutations in KEAP1, the negative regulator of transcription factor NRF2. CDO1 silencing promotes proliferation of non-small cell lung cancer cells by limiting the futile metabolism of cysteine to the wasteful and toxic byproducts CSA and sulfite, and depletion of cellular NADPH	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16878	-	-
Mus musculus	P60334	-	-

Expression

Organism	Comment	Expression
Homo sapiens	CDO1 is preferentially silenced by promoter methylation in human non-small cell lung cancers harboring mutations in KEAP1	down

General Information

General Information	Comment	Organism
physiological function	transcription factor NRF2, i.e. nuclear factor-erythroid 2 p45-related factor two, promotes the accumulation of intracellular cysteine and engages the cysteine homeostatic control mechanism mediated by cysteine dioxygenase 1	Homo sapiens
physiological function	transcription factor NRF2, i.e. nuclear factor-erythroid 2 p45-related factor two, promotes the accumulation of intracellular cysteine and engages the cysteine homeostatic control mechanism mediated by cysteine dioxygenase 1	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)