Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a therapeutic target in cancer treatment | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
isatin | mechanism of inhibition | Homo sapiens | |
additional information | isatin derivatives analysis as a class of TDO inhibitors, structure-activity relationships and molecular docking studies, and optimized the inhibition potency of isatin derivatives by over 130fold, overview. Hydrogen bond interactions between the compound and key active site residues of TDO, freedom upon rotation of the C3 chemical moiety and the presence of chlorines in the benzene ring of the compound comprise the properties that an isatin-based inhibitor requires to effectively inhibit the enzymatic activity of enzyme TDO | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
TDO | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | tryptophan 2,3-dioxygenase (TDO) has a immunomodulatory function that promotes tumoral immune resistance and proliferation | Homo sapiens |