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Literature summary for 1.11.1.9 extracted from
- Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets (2019), Free Radic. Biol. Med., 134, 385-393 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P11352 | isoform Gpx1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic islet | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GPX1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in mice overexpressing isoform Gpx1, activator protein AP-1 and albumin D box-binding protein (DBP) mRNA and protein levels are elevated in pacreatic islets compared with the wild-type islet. Their mRNA abundances in the cultured islets are elevated by ebselen and N-acetylcysteine, but decreased by H2O2. Both AP-1 and DBP can bind to the regenerating islet-derived protein Reg2 promoter in the overexpressing islets. Deleting the AP-1 and/or DBP binding domains in the Reg2 promoter attenuates and/or abolishes the inhibition of Reg2 promoter activation by ebselen as the Gpx1 mimic | Mus musculus |
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