Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not: ophthalmic acid | aves | |
additional information | not: ophthalmic acid | Chondrichthyes | |
additional information | not: ophthalmic acid | Mammalia | |
additional information | not: ophthalmic acid | Testudines | |
O2- | - |
aves | |
O2- | - |
Chondrichthyes | |
O2- | - |
Mammalia | |
O2- | - |
Testudines | |
Polyvalent anions | e.g. phosphate, sulfate, maleate | aves | |
Polyvalent anions | e.g. phosphate, sulfate, maleate | Chondrichthyes | |
Polyvalent anions | e.g. phosphate, sulfate, maleate | Mammalia | |
Polyvalent anions | e.g. phosphate, sulfate, maleate | Testudines |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mammalia | 5829 | - |
mitochondrial matrix | 25% of activity | Mammalia | 5759 | - |
additional information | not in peroxisomes | Mammalia | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
selenium | selenocysteine | Mammalia | |
selenium | selenocysteine | Chondrichthyes | |
selenium | selenocysteine | aves | |
selenium | selenocysteine | Testudines |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + ROOH | Mammalia | broad specificity for hydroperoxides | glutathione disulfide + ROH + H2O | - |
? | |
glutathione + ROOH | Chondrichthyes | broad specificity for hydroperoxides | glutathione disulfide + ROH + H2O | - |
? | |
glutathione + ROOH | aves | broad specificity for hydroperoxides | glutathione disulfide + ROH + H2O | - |
? | |
glutathione + ROOH | Testudines | broad specificity for hydroperoxides | glutathione disulfide + ROH + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
aves | - |
- |
- |
Chondrichthyes | - |
- |
- |
Mammalia | - |
- |
- |
no activity in plants | - |
- |
- |
Testudines | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 glutathione + H2O2 = glutathione disulfide + 2 H2O | mechanism | Mammalia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + ROOH | broad specificity for hydroperoxides | Mammalia | glutathione disulfide + ROH + H2O | - |
? | |
glutathione + ROOH | broad specificity for hydroperoxides | Chondrichthyes | glutathione disulfide + ROH + H2O | - |
? | |
glutathione + ROOH | broad specificity for hydroperoxides | aves | glutathione disulfide + ROH + H2O | - |
? | |
glutathione + ROOH | broad specificity for hydroperoxides | Testudines | glutathione disulfide + ROH + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Mammalia |