Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-dihydroxy-4-[[(2E,6E,10E)-12-hydroxy-2,6,10-trimethyldodeca-2,6,10-trien-1-yl]oxy]benzoic acid | - |
Trypanosoma brucei brucei | |
2-fluoro-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid | - |
Trypanosoma brucei brucei | |
2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-6-methylbenzoic acid | - |
Trypanosoma brucei brucei | |
2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid | - |
Trypanosoma brucei brucei | |
4-[(14-bromotetradecyl)oxy]-2-hydroxybenzaldehyde | - |
Trypanosoma brucei brucei | |
4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-2-methylbenzoic acid | - |
Trypanosoma brucei brucei | |
ascofuranone | - |
Trypanosoma brucei brucei | |
methyl 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoate | - |
Trypanosoma brucei brucei | |
methyl 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzoate | - |
Trypanosoma brucei brucei | |
Salicylhydroxamic acid | - |
Trypanosoma brucei brucei | |
[14-(4-carboxy-3-hydroxy-5-methylphenoxy)tetradecyl](triphenyl)phosphanium | - |
Trypanosoma brucei brucei | |
[14-(4-formyl-3-hydroxyphenoxy)tetradecyl](triphenyl)phosphanium | - |
Trypanosoma brucei brucei | |
[14-[3-fluoro-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium | - |
Trypanosoma brucei brucei | |
[14-[3-hydroxy-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium | - |
Trypanosoma brucei brucei | |
[14-[4-(ethoxycarbonyl)-3-hydroxy-5-methylphenoxy]tetradecyl](triphenyl)phosphanium | - |
Trypanosoma brucei brucei | |
[14-[4-hydroxy-3-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium | - |
Trypanosoma brucei brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound to | Trypanosoma brucei brucei | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | diiron protein | Trypanosoma brucei brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei brucei | Q26710 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Trypanosoma brucei brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ubiquinol + O2 | - |
Trypanosoma brucei brucei | 2 ubiquinone + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alternative oxidase | - |
Trypanosoma brucei brucei |
TAO | - |
Trypanosoma brucei brucei |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
pH and temperature not specified in the publication | Trypanosoma brucei brucei | ascofuranone | |
0.0000031 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | 2,6-dihydroxy-4-[[(2E,6E,10E)-12-hydroxy-2,6,10-trimethyldodeca-2,6,10-trien-1-yl]oxy]benzoic acid | |
0.0000042 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | [14-(4-carboxy-3-hydroxy-5-methylphenoxy)tetradecyl](triphenyl)phosphanium | |
0.000012 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | [14-[4-hydroxy-3-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium | |
0.000015 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | [14-[3-hydroxy-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium | |
0.0000176 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzaldehyde | |
0.00022 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | [14-(4-formyl-3-hydroxyphenoxy)tetradecyl](triphenyl)phosphanium | |
0.00025 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | [14-[4-(ethoxycarbonyl)-3-hydroxy-5-methylphenoxy]tetradecyl](triphenyl)phosphanium | |
0.00074 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | [14-[3-fluoro-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium | |
0.00092 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | 4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-2-methylbenzoic acid | |
0.0011 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | 2-fluoro-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid | |
0.00169 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | methyl 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoate | |
0.0021 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid | |
0.0023 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | methyl 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzoate | |
0.0024 | - |
37°C, pH not specified in the publication | Trypanosoma brucei brucei | 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-6-methylbenzoic acid | |
0.00593 | - |
pH and temperature not specified in the publication | Trypanosoma brucei brucei | Salicylhydroxamic acid |
General Information | Comment | Organism |
---|---|---|
drug target | validated as a drug target against trypanosomes | Trypanosoma brucei brucei |
physiological function | critical enzyme for the respiration of bloodstream forms of trypanosomes | Trypanosoma brucei brucei |