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Literature summary for 1.1.3.9 extracted from
- Radiation inactivation of galactose oxidase, a monomeric enzyme with a stable free radical (2010), Protein Sci., 19, 236-241.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | in both active and inactive forms, protein monomer integrity is lost with a single radiation interaction anywhere in the polypeptide, but enzymatic activity is more resistant, yielding target sizes considerably smaller than that of the monomer | Hypomyces rosellus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | essentially required, copper enzyme, removal of copper and free radicals inactivates the enzyme | Hypomyces rosellus |  |
| additional information | the monomeric enzyme containing a mononuclear copper ionis coordinated with an unusually stable cysteinyl-tyrosine protein free radical, removal of copper and free radicals inactivates the enzyme | Hypomyces rosellus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 68000 | - |
1 * 68000, SDS-PAGE | Hypomyces rosellus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-galactose + O2 | Hypomyces rosellus | - |
D-galacto-hexodialdose + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hypomyces rosellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| the enzyme from commercial preparation is further purified by gel filtration | Hypomyces rosellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Hypomyces rosellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-galactose + O2 | - |
Hypomyces rosellus | D-galacto-hexodialdose + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 68000, SDS-PAGE | Hypomyces rosellus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
assay at | Hypomyces rosellus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | the structure of galactose oxidase must make its catalytic activity unusually robust, permitting the enzymatic properties to survive in molecules following cleavage of the polymer chain | Hypomyces rosellus |
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Release 2023.1 (January 2023)
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