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Literature summary for 1.1.3.8 extracted from
- L-Gulono-gamma-lactone oxidase (rat and goat liver) (1979), Methods Enzymol., 62, 24-30.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.066 | - |
L-gulono-1,4-lactone | - |
Rattus norvegicus |  |
| 0.15 | - |
L-gulono-1,4-lactone | - |
Capra hircus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Capra hircus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 51000 | - |
x * 51000, SDS-PAGE | Rattus norvegicus |
| 51000 | - |
x * 51000, SDS-PAGE | Capra hircus |
| 500000 | - |
gel filtration | Rattus norvegicus |
| 500000 | - |
gel filtration | Capra hircus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-gulono-1,4-lactone + O2 | Rattus norvegicus | - |
L-xylo-hex-3-ulonolactone + H2O2 | - |
? | |
| L-gulono-1,4-lactone + O2 | Capra hircus | - |
L-xylo-hex-3-ulonolactone + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Capra hircus | - |
- |
- |
| no activity in Cavia porcellus | - |
guinea pig | - |
| no activity in Homo sapiens | - |
- |
- |
| no activity in primates | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
- |
Capra hircus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 | product isomerizes spontaneously to L-ascorbate | Rattus norvegicus | |
| L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 | product isomerizes spontaneously to L-ascorbate | Capra hircus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Capra hircus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.54 | - |
- |
Rattus norvegicus |
| 2.05 | - |
- |
Capra hircus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-gulono-1,4-lactone + O2 | - |
Rattus norvegicus | L-xylo-hex-3-ulonolactone + H2O2 | - |
? | |
| L-gulono-1,4-lactone + O2 | - |
Capra hircus | L-xylo-hex-3-ulonolactone + H2O2 | - |
? | |
| L-gulono-1,4-lactone + O2 | - |
Rattus norvegicus | L-xylo-hex-3-ulonolactone + H2O2 | product isomerizes spontaneously to L-ascorbate | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| oligomer | x * 51000, SDS-PAGE | Rattus norvegicus |
| oligomer | x * 51000, SDS-PAGE | Capra hircus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | 8alpha-(N1-histidyl)riboflavin is the cofactor structure determined by high-voltage paper electrophoresis | Rattus norvegicus | |
| FAD | 8alpha-(N1-histidyl)riboflavin is the cofactor structure determined by high-voltage paper electrophoresis | Capra hircus | |
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