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Literature summary for 1.1.3.37 extracted from
- Deletion of vitamin C biosynthesis enzyme, arabino-1, 4-lactone oxidase in Leishmania donovani results in increased pro-inflammatory responses from host immune cells (2014), Mol. Microbiol., 91, 1227-1239.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-arabinono-1,4-lactone + O2 | Leishmania donovani | - |
dehydro-D-arabinono-1,4-lactone + H2O2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| promastigote | - |
Leishmania donovani | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-arabinono-1,4-lactone + O2 | - |
Leishmania donovani | dehydro-D-arabinono-1,4-lactone + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALO | - |
Leishmania donovani |
| arabino-1,4-lactone oxidase | - |
Leishmania donovani |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme deletion in Leishmania donovani results in increased pro-inflammatory responses from host immune cells. Enzyme null mutant parasites show growth defect and loss in virulence | Leishmania donovani |
| metabolism | the enzyme catalyses the last step in ascorbate biosynthesis pathway | Leishmania donovani |
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