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Literature summary for 1.1.3.17 extracted from
- Relative timing of hydrogen and proton transfers in the reaction of flavin oxidation catalyzed by choline oxidase (2013), Biochemistry, 52, 1221-1226.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | stopped-flow kinetics of oxidative half-reaction, deuterium kinetic isotope effects in steady-state kinetics, e.g.. second-order rate constants, overview | Arthrobacter globiformis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| choline + 2 O2 + H2O | Arthrobacter globiformis | - |
betaine + 2 H2O2 | - |
? |  |
| choline + 2 O2 + H2O | Arthrobacter globiformis ATCC 8010 | - |
betaine + 2 H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arthrobacter globiformis | - |
- |
- |
| Arthrobacter globiformis ATCC 8010 | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| choline + 2 O2 + H2O = betaine + 2 H2O2 | reaction mechanism of reductive and oxidative half-reactions, determination of a mechanism of flavin oxidation that directly results in the formation of oxidized flavin and hydrogen peroxide without stabilization of reaction intermediates, overview | Arthrobacter globiformis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Arthrobacter globiformis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| choline + 2 O2 + H2O | - |
Arthrobacter globiformis | betaine + 2 H2O2 | - |
? | |
| choline + 2 O2 + H2O | - |
Arthrobacter globiformis ATCC 8010 | betaine + 2 H2O2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Arthrobacter globiformis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | assay at | Arthrobacter globiformis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 10 | kcat/Kox with choline or 1,2-[2H4]choline as a substrate for choline oxidase is independent of pH between pH 6.0 and pH 10.0 | Arthrobacter globiformis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Arthrobacter globiformis | |
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Release 2023.1 (January 2023)
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