Application | Comment | Organism |
---|---|---|
diagnostics | the metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival. Dysregulation of HAO2 is a very early event in the development of hepatocellular carcinoma and it may represent a useful diagnostic and prognostic marker for human hepatocellular carcinoma | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene HAO2, quantitative RT-PCR enzyme expression analysis | Rattus norvegicus |
gene HAO2, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
gene HAO2, quantitative RT-PCR enzyme expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | Rattus norvegicus hepatocellular carcinoma cells are transduced by a HAO2 encoding lentiviral vector and grafted in mice | Rattus norvegicus |
additional information | Rattus norvegicus hepatocellular carcinoma cells are transduced by a HAO2 encoding lentiviral vector and grafted in mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Rattus norvegicus | 5777 | - |
peroxisome | - |
Homo sapiens | 5777 | - |
peroxisome | - |
Mus musculus | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
an (S)-2-hydroxy carboxylate + O2 | Rattus norvegicus | - |
a 2-oxo carboxylate + H2O2 | - |
? | |
an (S)-2-hydroxy carboxylate + O2 | Homo sapiens | - |
a 2-oxo carboxylate + H2O2 | - |
? | |
an (S)-2-hydroxy carboxylate + O2 | Mus musculus | - |
a 2-oxo carboxylate + H2O2 | - |
? | |
an (S)-2-hydroxy carboxylate + O2 | Mus musculus C3H | - |
a 2-oxo carboxylate + H2O2 | - |
? | |
an (S)-2-hydroxy carboxylate + O2 | Rattus norvegicus Fischer 344 | - |
a 2-oxo carboxylate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NYQ3 | - |
- |
Mus musculus | Q9NYQ2 | - |
- |
Mus musculus C3H | Q9NYQ2 | - |
- |
Rattus norvegicus | Q07523 | - |
- |
Rattus norvegicus Fischer 344 | Q07523 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | HAO2 is downregulated | Mus musculus | - |
hepatocellular carcinoma cell | Hao2 is highly significantly downregulated in 12/12 HCCs developed by the CMD protocol and in 16/16 HCCs generated by chronic DENA treatment | Rattus norvegicus | - |
hepatocellular carcinoma cell | HAO2 mRNA levels are strongly downregulated in two distinct series of human HCCs, when compared to both normal and cirrhotic peritumoral liver, overview | Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
an (S)-2-hydroxy carboxylate + O2 | - |
Rattus norvegicus | a 2-oxo carboxylate + H2O2 | - |
? | |
an (S)-2-hydroxy carboxylate + O2 | - |
Homo sapiens | a 2-oxo carboxylate + H2O2 | - |
? | |
an (S)-2-hydroxy carboxylate + O2 | - |
Mus musculus | a 2-oxo carboxylate + H2O2 | - |
? | |
an (S)-2-hydroxy carboxylate + O2 | - |
Mus musculus C3H | a 2-oxo carboxylate + H2O2 | - |
? | |
an (S)-2-hydroxy carboxylate + O2 | - |
Rattus norvegicus Fischer 344 | a 2-oxo carboxylate + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hao2 | - |
Rattus norvegicus |
Hao2 | - |
Homo sapiens |
Hao2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FMN | dependent on | Rattus norvegicus | |
FMN | dependent on | Homo sapiens | |
FMN | dependent on | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents | down |
Homo sapiens | the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents | down |
Mus musculus | the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents | down |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the family of L-2-hydroxy acid oxidases | Rattus norvegicus |
evolution | the enzyme belongs to the family of L-2-hydroxy acid oxidases | Homo sapiens |
evolution | the enzyme belongs to the family of L-2-hydroxy acid oxidases | Mus musculus |
physiological function | L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis | Rattus norvegicus |
physiological function | L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis | Homo sapiens |
physiological function | L-2-hydroxy acid oxidases are flavin mononucleotide-dependent peroxisomal enzymes, responsible for the oxidation of L-2-hydroxy acids to ketoacids, resulting in the formation of hydrogen peroxide. Oncosuppressive role of HAO2 in hepatocarcinogenesis | Mus musculus |