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Literature summary for 1.1.3.15 extracted from

  • Liu, L.; Tong, H.; Dong, X.
    Function of the pyruvate oxidase-lactate oxidase cascade in interspecies competition between Streptococcus oligofermentans and Streptococcus mutans (2012), Appl. Environ. Microbiol., 78, 2120-2127.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate + O2 Streptococcus cristatus
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pyruvate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus cristatus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme is expressed throughout the growth phase, and expression of the lox gene increases by about 2.5fold when cells enter the stationary phase Streptococcus cristatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + O2
-
Streptococcus cristatus pyruvate + H2O2
-
?

Synonyms

Synonyms Comment Organism
lactate oxidase
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Streptococcus cristatus
LOX
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Streptococcus cristatus

General Information

General Information Comment Organism
metabolism inactivation of gene pox encoding pyruvate oxidase causes a dramatic reduction in H2O2 production from lactate, suggesting a synergistic action of the two oxidases in converting lactate into H2O2. The pox mutant of Streptomyces oligofermentans fails to inhibit Streptomyces mutans even though lox is active Streptococcus cristatus
physiological function H2O2 production, especially lactate oxidase, allows Streptomyces oligofermentans to out-compete Streptomyces mutans in oral commensals, the enzyme mainly contributes to H2O2 production in stationary phase. But lactate oxidase requires cofunction of pyruvate oxidase for successfully inhibiting Streptomyces mutans Streptococcus cristatus