Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.3.15 extracted from

  • Schuman, M.; Massey, V.
    Effect of anions on the catalytic activity of pig liver glycolic acid oxidase (1971), Biochim. Biophys. Acta, 227, 521-537.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
arsenate increasing activity up to 0.1 M, inhibition of ferricyanide-linked assay above 0.1 M Sus scrofa
phosphate increasing activity up to 0.1 M, inhibition of ferricyanide-linked assay above 0.1 M Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
acetate
-
Sus scrofa
arsenate inhibition of glycolate-ferricyanide or glyoxylate-ferricyanide assay above 0.1 M Sus scrofa
Butyrate
-
Sus scrofa
glycolate inhibition above 1.7 mM Sus scrofa
Heptanoate
-
Sus scrofa
hexanoate
-
Sus scrofa
malonate
-
Sus scrofa
oxalate
-
Sus scrofa
phosphate inhibition of glycolate-ferricyanide or glyoxylate-ferricyanide assay above 0.1 M Sus scrofa
propionate
-
Sus scrofa
succinate
-
Sus scrofa
valerate
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.28
-
dichlorophenolindophenol cosubstrate: glycolate Sus scrofa
0.42
-
glycolate cosubstrate: 2,6-dichlorophenolindophenol Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycolate + O2 Sus scrofa
-
glyoxylate + H2O2
-
?
glyoxylate + O2 Sus scrofa
-
? + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
pig
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycolate + 2,6-dichlorophenolindophenol
-
Sus scrofa glyoxylate + reduced 2,6-dichlorophenolindophenol
-
?
glycolate + ferricyanide
-
Sus scrofa glyoxylate + ferrocyanide
-
?
glycolate + O2
-
Sus scrofa glyoxylate + H2O2
-
?
glyoxylate + 2,6-dichlorophenolindophenol
-
Sus scrofa ? + reduced 2,6-dichlorophenolindophenol
-
?
glyoxylate + ferricyanide
-
Sus scrofa ? + ferrocyanide
-
?
glyoxylate + O2
-
Sus scrofa ? + H2O2
-
?

Cofactor

Cofactor Comment Organism Structure
FMN
-
Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information straight-chain monocarboxylic acids are non-competitive inhibitors with either glycolate or glyoxylate as substrates, dicarboxylic acids are competitive inhibitors with glycolate as substrate, but non-competitive inhibitors for glyoxylate as substrate Sus scrofa
0.092
-
Heptanoate non-competitive, glycolate oxidation Sus scrofa
0.3
-
hexanoate non-competitive, glycolate oxidation Sus scrofa
0.44
-
oxalate competitive, glycolate oxidation, non-competitive for glyoxylate oxidation Sus scrofa
1.2
-
valerate non-competitive, glyoxylate reduction Sus scrofa
1.3
-
valerate non-competitive, glycolate oxidation Sus scrofa
3.6
-
Butyrate non-competitive, glycolate oxidation Sus scrofa
8.2
-
malonate non-competitive, glyoxylate reduction Sus scrofa
9.2
-
malonate competitive, glycolate oxidation Sus scrofa
9.5
-
propionate non-competitive, glycolate oxidation Sus scrofa
14
-
succinate competitive, glycolate oxidation Sus scrofa
17
-
propionate non-competitive, glyoxylate reduction Sus scrofa
37
-
acetate non-competitive, glycolate oxidation Sus scrofa
48
-
acetate non-competitive, glyoxylate reduction Sus scrofa