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Literature summary for 1.1.3.13 extracted from

  • Nichols, C.S.; Cromartie, T.H.
    Irreversible inactivation of the flavoenzyme alcohol, oxidase with acetylenic alcohols (1980), Biochem. Biophys. Res. Commun., 97, 216-221.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,4-butynediol
-
[Candida] boidinii
4-Hydroxy-2-butynal irreversible [Candida] boidinii
Propynal
-
[Candida] boidinii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.44
-
4-Hydroxy-2-butynal
-
[Candida] boidinii
3
-
methanol
-
[Candida] boidinii
10
-
2-propin-1-ol
-
[Candida] boidinii
36
-
1,4-butynediol
-
[Candida] boidinii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methanol + O2 [Candida] boidinii key enzyme of methanol metabolism formaldehyde + H2O2
-
?

Organism

Organism UniProt Comment Textmining
[Candida] boidinii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,4-butynediol + O2 oxidized to mechanism-based irreversible inactivator: 4-hydroxy-2-butynal [Candida] boidinii 4-hydroxy-2-butyn-1-al + H2O2 mechanism-based inhibitor ?
2-propyn-1-ol + O2 oxidized to mechanism-based irreversible inactivator: propynal [Candida] boidinii propyn-1-al + H2O2 mechanism-based inhibitor ?
methanol + O2
-
[Candida] boidinii formaldehyde + H2O2
-
?
methanol + O2 key enzyme of methanol metabolism [Candida] boidinii formaldehyde + H2O2
-
?

Cofactor

Cofactor Comment Organism Structure
FAD
-
[Candida] boidinii

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.42
-
4-Hydroxy-2-butynal
-
[Candida] boidinii