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Literature summary for 1.1.2.7 extracted from

  • Jongejan, A.; Jongejan, J.A.; Hagen, W.R.
    Direct hydride transfer in the reaction mechanism of quinoprotein alcohol dehydrogenases: a quantum mechanical investigation (2001), J. Comput. Chem., 22, 1732-1749.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity, functional role analysis, overview Methylorubrum extorquens
Ca2+ required for activity, functional role analysis, overview Methylophilus methylotrophus

Organism

Organism UniProt Comment Textmining
Methylophilus methylotrophus P38539 and P38540 P38539 (large subunit, alpha) and P38540 (small subunit, beta)
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Methylorubrum extorquens P16027 and P14775 P16027 (large subunit, alpha) and P14775 (small subunit, beta)
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Reaction

Reaction Comment Organism Reaction ID
a primary alcohol + 2 ferricytochrome cL = an aldehyde + 2 ferrocytochrome cL + 2 H+ catalytic mechanism, ping-pong kinetic schemes, and transition state structures, analysis by ab initio quantum mechanical methods, hydride transfer from the Calpha-position of the substrate alcohol or aldehyde directly to the C-5 carbon of PQQ is energetically feasible, detailed overview Methylorubrum extorquens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information oxidation of alcohols by direct hydride transfer to the pyrroloquinoline quinone cofactor Methylorubrum extorquens ?
-
?
additional information oxidation of alcohols by direct hydride transfer to the pyrroloquinoline quinone cofactor, catalytic mechanism, ping-pong kinetic schemes, and transition state structures, analysis by ab initio quantum mechanical methods, hydride transfer from the Calpha-position of the substrate alcohol or aldehyde directly to the C-5 carbon of PQQ is energetically feasible, detailed overview Methylophilus methylotrophus ?
-
?

Synonyms

Synonyms Comment Organism
MDH
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Methylorubrum extorquens
MDH
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Methylophilus methylotrophus
methanol dehydrogenase
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Methylorubrum extorquens
methanol dehydrogenase
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Methylophilus methylotrophus
QH-ADH
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Methylorubrum extorquens
QH-ADH
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Methylophilus methylotrophus
quinohemoprotein alcohol dehydrogenase
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Methylorubrum extorquens
quinohemoprotein alcohol dehydrogenase
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Methylophilus methylotrophus
quinoprotein alcohol dehydrogenase
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Methylorubrum extorquens
quinoprotein alcohol dehydrogenase
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Methylophilus methylotrophus

Cofactor

Cofactor Comment Organism Structure
pyrroloquinoline quinone i.e. 2,7,9-tricarboxy-1H-pyrrolo[2,3-f]quinoline-4,5-dione, PQQ, structures of anionic PQQ, neutral PQQ, and reduced PQQ, overview Methylorubrum extorquens
pyrroloquinoline quinone i.e. 2,7,9-tricarboxy-1H-pyrrolo[2,3-f]quinoline-4,5-dione, PQQ, structures of anionic PQQ, neutral PQQ, and reduced PQQ, overview Methylophilus methylotrophus