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Literature summary for 1.1.2.4 extracted from

  • Hatefi, Y.; Stiggall, D.L.
    Metal-containing flavoprotein dehydrogenases (1976), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 13, 175-297.
No PubMed abstract available
Search for more literature for 1.1.2.4

Inhibitors

Inhibitors Comment Organism Structure
o-phenanthroline
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0054
-
 cytochrome c
-
 Saccharomyces cerevisiae
0.285
-
 D-lactate
-
 Saccharomyces cerevisiae
1.4
-
 D-2-hydroxybutyrate
-
 Saccharomyces cerevisiae
4.45
-
 oxidized phenazine methosulfate
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ restores activity after inhibition with o-phenanthroline Saccharomyces cerevisiae
ferricyanide not suitable as electron acceptor Saccharomyces cerevisiae
Mn2+ restores activity after inhibition with o-phenanthroline Saccharomyces cerevisiae
Zn2+ very tightly bound to enzyme Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 sedimentation equilibrium centrifugation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-lactate + 2 ferricytochrome c Saccharomyces cerevisiae
-
 pyruvate + ferrocytochrome c
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-lactate + 2 ferricytochrome c
-
 Saccharomyces cerevisiae pyruvate + ferrocytochrome c
-
 ?
(R)-lactate + ferricytochrome c
-
 Saccharomyces cerevisiae pyruvate + ferrocytochrome c
-
 ?
D-2-hydroxybutyrate + cytochrome c
-
 Saccharomyces cerevisiae 2-oxobutanoate + ferrocytochrome c
-
 ?
D-lactate + oxidized phenazine methosulfate
-
 Saccharomyces cerevisiae pyruvate + reduced phenazine methosulfate + H+
-
 r

Cofactor

Cofactor Comment Organism Structure
2,6-dichlorophenolindophenol can substitute for cytochrome c Saccharomyces cerevisiae
cytochrome c
-
 Saccharomyces cerevisiae
FAD
-
 Saccharomyces cerevisiae
phenazine methosulfate can substitute for cytochrome c Saccharomyces cerevisiae