Application | Comment | Organism |
---|---|---|
synthesis | the enzyme can be used for synthesis of optically pure 3-quinuclidinol. Optically pure 3-quinuclidinol is an important intermediate for the synthesis of various anticholinergic drugs. (S)-3-Quinuclidinol is a very promising chiral building blocks for synthesis of serotonin receptor antagonist drugs and anticholinergic drugs | Rhodococcus erythropolis |
Cloned (Comment) | Organism |
---|---|
phylogenetic tree | Rhodococcus erythropolis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-quinuclidinone + NADPH + H+ | Rhodococcus erythropolis | stereospecific reduction of 3-quinuclidinone | (S)-3-quinuclidinol + NADP+ | - |
? | |
3-quinuclidinone + NADPH + H+ | Rhodococcus erythropolis WY1406 | stereospecific reduction of 3-quinuclidinone | (S)-3-quinuclidinol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rhodococcus erythropolis | - |
- |
- |
Rhodococcus erythropolis WY1406 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | strain WY1406 utilizes most of the tested sugars, i.e. D-glucose, glycerol, maltose, sucrose, arabinose, sorbitol, except mannitol, for growth | Rhodococcus erythropolis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-quinuclidinone + NADPH + H+ | stereospecific reduction of 3-quinuclidinone | Rhodococcus erythropolis | (S)-3-quinuclidinol + NADP+ | - |
? | |
3-quinuclidinone + NADPH + H+ | stereospecific reduction of 3-quinuclidinone with over 99% enantiomeric excess, effects of concentration of 3-quinuclidinone hydrochloride, overview | Rhodococcus erythropolis | (S)-3-quinuclidinol + NADP+ | - |
? | |
3-quinuclidinone + NADPH + H+ | stereospecific reduction of 3-quinuclidinone | Rhodococcus erythropolis WY1406 | (S)-3-quinuclidinol + NADP+ | - |
? | |
3-quinuclidinone + NADPH + H+ | stereospecific reduction of 3-quinuclidinone with over 99% enantiomeric excess, effects of concentration of 3-quinuclidinone hydrochloride, overview | Rhodococcus erythropolis WY1406 | (S)-3-quinuclidinol + NADP+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Rhodococcus erythropolis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | - |
Rhodococcus erythropolis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rhodococcus erythropolis |