Literature summary for 1.1.1.B51 extracted from

Wang, Y.; Li, J.; Wu, Q.; Zhu, D.
Microbial stereospecific reduction of 3-quinuclidinone with newly isolated Nocardia sp. and Rhodococcus erythropolis (2013), J. Mol. Catal. B, 88, 14-19 .

No PubMed abstract available

Search for more literature for 1.1.1.B51

Application

Application	Comment	Organism
synthesis	the enzyme can be used for synthesis of optically pure 3-quinuclidinol. Optically pure 3-quinuclidinol is an important intermediate for the synthesis of various anticholinergic drugs. (R)-3-Quinuclidinol is used to synthesize muscarinic M1 or M3 receptor antagonists such as talsaclidine, revatropate, and solifenacin	Nocardia sp. WY1202

Cloned(Commentary)

Cloned (Comment)	Organism
phylogenetic tree	Nocardia sp. WY1202

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3-quinuclidinone + NADPH + H+	Nocardia sp. WY1202	stereospecific reduction of 3-quinuclidinone	(R)-3-quinuclidinol + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Nocardia sp. WY1202	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	apart from D-glucose and glycerol, various sugars and alcohols like maltose, sucrose, arabinose, mannitol, sorbitol are not utilized by strain WY1202 for growth	Nocardia sp. WY1202	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-quinuclidinone + NADPH + H+	stereospecific reduction of 3-quinuclidinone	Nocardia sp. WY1202	(R)-3-quinuclidinol + NADP+	-	?
3-quinuclidinone + NADPH + H+	stereospecific reduction of 3-quinuclidinone with over 85-95% enantiomeric excess, effects of concentration of 3-quinuclidinone hydrochloride, overview	Nocardia sp. WY1202	(R)-3-quinuclidinol + NADP+	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	-	Nocardia sp. WY1202

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	-	Nocardia sp. WY1202

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Nocardia sp. WY1202

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Release 2023.1 (January 2023)