Inhibitors | Comment | Organism | Structure |
---|---|---|---|
di-n-butyl phthalate | - |
Homo sapiens | |
di-n-butyl phthalate | - |
Rattus norvegicus | |
di-n-octyl phthalate | - |
Homo sapiens | |
di-n-octyl phthalate | - |
Rattus norvegicus | |
di-n-pentyl phthalate | - |
Homo sapiens | |
di-n-pentyl phthalate | - |
Rattus norvegicus | |
dicyclohexyl phthalate | - |
Homo sapiens | |
dicyclohexyl phthalate | - |
Rattus norvegicus | |
diethyl phthalate | - |
Homo sapiens | |
diethyl phthalate | - |
Rattus norvegicus | |
dipropyl phthalate | - |
Homo sapiens | |
dipropyl phthalate | - |
Rattus norvegicus | |
mono (2-ethylhexyl) phthalate | competitive inhibitor of 11beta-HSD2, possibly via competing with the cofactor NAD+ | Homo sapiens | |
mono (2-ethylhexyl) phthalate | competitive inhibitor of 11beta-HSD2, possibly via competing with the cofactor NAD+ | Rattus norvegicus | |
additional information | not inhibited by dimethyl phthalate, butylbenzyl phthalate, di(2-ethylhexyl) phthalate, di-n-heptyl phthalate, diisononyl phthalate, and diisodecyl phthalate | Homo sapiens | |
additional information | not inhibited by dimethyl phthalate, butylbenzyl phthalate, di(2-ethylhexyl) phthalate, di-n-heptyl phthalate, diisononyl phthalate, and diisodecyl phthalate | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NAD+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADH + H+ | - |
? | |
corticosterone + NAD+ | - |
Rattus norvegicus | 11-dehydrocorticosterone + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD2 | - |
Homo sapiens |
11beta-HSD2 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase 2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase 2 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.01369 | - |
- |
Rattus norvegicus | di-n-butyl phthalate | |
0.03264 | - |
- |
Rattus norvegicus | dicyclohexyl phthalate | |
0.08559 | - |
- |
Rattus norvegicus | dipropyl phthalate | |
0.1108 | - |
- |
Homo sapiens | mono (2-ethylhexyl) phthalate | |
0.1218 | - |
- |
Rattus norvegicus | mono (2-ethylhexyl) phthalate |