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Literature summary for 1.1.1.B40 extracted from

  • Honda, Y.; Ohno, S.; Nakajin, S.
    Leydig cells from neonatal pig testis abundantly express 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 2 and effectively inactivate cortisol to cortisone (2008), J. Steroid Biochem. Mol. Biol., 108, 91-101.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00038
-
cortisol type 2 enzyme, 34°C, pH 7.4 Sus scrofa
0.00136
-
cortisol type 1 enzyme, 34°C, pH 7.4 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Sus scrofa
-
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Leydig cell of neonatal pig. High expression of 11beta-hydroxysteroid dehydrogenase type 2 mRNA, resulting in oxidation from cortisol to cortison, with no detection of the reduction reaction. Activity of type 2 enzyme is higher than the oxidation activity of the type 1 enzyme Sus scrofa
-
testis of neonatal pig Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+
-
Sus scrofa cortisone + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Sus scrofa
NADH
-
Sus scrofa