Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-Dehydrocorticosterone | inhibition of isozyme 11beta-HSD2 | Ovis aries | |
11-dehydrocortisterone | - |
Ovis aries | |
11-oxo-3beta,5alpha-tetrathydrotestosterone | - |
Ovis aries | |
11-oxo-allopregnanolone | inhibition of both isozymes 11beta-HSD1 and of isozyme 11beta-HSD2 | Ovis aries | |
11-oxo-progesterone | - |
Ovis aries | |
11-oxo-testosterone | - |
Ovis aries | |
11beta-hydroxy-allopregnanolone | - |
Ovis aries | |
11beta-hydroxyandrostanediol | - |
Ovis aries | |
11beta-hydroxyandrostenedione | - |
Ovis aries | |
11beta-hydroxyprogesterone | - |
Ovis aries | |
11beta-hydroxytestosterone | inhibition of both isozymes 11beta-HSD1 and of isozyme 11beta-HSD2 | Ovis aries | |
3alpha,5alpha-tetrahydro-11-dehydrocorticosterone | - |
Ovis aries | |
3alpha,5alpha-tetrahydro-dehydrocortisterone | - |
Ovis aries | |
3alpha,5alpha-tetrahydroaldosterone | - |
Ovis aries | |
3alpha,5alpha-tetrahydrocorticosterone | inhibition of isozyme 11beta-HSD1 and isozyme isozyme 11beta-HSD2 | Ovis aries | |
3alpha,5alpha-tetrahydrocortisol | - |
Ovis aries | |
5alpha-dihydrocorticosterone | - |
Ovis aries | |
additional information | steroid hormones, adrenocorticosteroid derivatives, progesteron and androgen steroid hormones, with 5alpha-ring A reduced-configuration selectively inhibit isozyme 11beta-HSD2, while 5beta-derivatives are inactive | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Ovis aries | - |
kidney | - |
Ovis aries | - |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD2 | - |
Ovis aries |
11beta-hydroxysteroid dehydrogenase isoforms 2 | - |
Ovis aries |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Ovis aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.4 | - |
assay at | Ovis aries |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxyprogesterone | |
0.00012 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxy-allopregnanolone | |
0.00015 | - |
pH 8.4, 37°C | Ovis aries | 5alpha-dihydrocorticosterone | |
0.00026 | - |
pH 8.4, 37°C | Ovis aries | 3alpha,5alpha-tetrahydrocorticosterone | |
0.00035 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxytestosterone | |
0.0004 | - |
pH 8.4, 37°C | Ovis aries | 11-oxo-progesterone | |
0.00047 | - |
pH 8.4, 37°C | Ovis aries | 11-dehydrocortisterone | |
0.0005 | - |
pH 8.4, 37°C | Ovis aries | 3alpha,5alpha-tetrahydroaldosterone | |
0.0008 | - |
pH 8.4, 37°C | Ovis aries | 3alpha,5alpha-tetrahydro-dehydrocortisterone | |
0.00135 | - |
pH 8.4, 37°C | Ovis aries | 11-oxo-testosterone | |
0.0015 | - |
pH 8.4, 37°C | Ovis aries | 11-oxo-allopregnanolone | |
0.0045 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxyandrostanediol | |
0.0078 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxyandrostenedione | |
0.008 | - |
pH 8.4, 37°C | Ovis aries | 3alpha,5alpha-tetrahydrocortisol | |
0.008 | - |
pH 8.4, 37°C | Ovis aries | 11-oxo-3beta,5alpha-tetrathydrotestosterone |