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Literature summary for 1.1.1.B40 extracted from

  • Latif, S.A.; Pardo, H.A.; Hardy, M.P.; Morris, D.J.
    Endogenous selective inhibitors of 11beta-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin (2005), Mol. Cell. Endocrinol., 243, 43-50.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
11-Dehydrocorticosterone inhibition of isozyme 11beta-HSD2 Ovis aries
11-dehydrocortisterone
-
Ovis aries
11-oxo-3beta,5alpha-tetrathydrotestosterone
-
Ovis aries
11-oxo-allopregnanolone inhibition of both isozymes 11beta-HSD1 and of isozyme 11beta-HSD2 Ovis aries
11-oxo-progesterone
-
Ovis aries
11-oxo-testosterone
-
Ovis aries
11beta-hydroxy-allopregnanolone
-
Ovis aries
11beta-hydroxyandrostanediol
-
Ovis aries
11beta-hydroxyandrostenedione
-
Ovis aries
11beta-hydroxyprogesterone
-
Ovis aries
11beta-hydroxytestosterone inhibition of both isozymes 11beta-HSD1 and of isozyme 11beta-HSD2 Ovis aries
3alpha,5alpha-tetrahydro-11-dehydrocorticosterone
-
Ovis aries
3alpha,5alpha-tetrahydro-dehydrocortisterone
-
Ovis aries
3alpha,5alpha-tetrahydroaldosterone
-
Ovis aries
3alpha,5alpha-tetrahydrocorticosterone inhibition of isozyme 11beta-HSD1 and isozyme isozyme 11beta-HSD2 Ovis aries
3alpha,5alpha-tetrahydrocortisol
-
Ovis aries
5alpha-dihydrocorticosterone
-
Ovis aries
additional information steroid hormones, adrenocorticosteroid derivatives, progesteron and androgen steroid hormones, with 5alpha-ring A reduced-configuration selectively inhibit isozyme 11beta-HSD2, while 5beta-derivatives are inactive Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Ovis aries
-
kidney
-
Ovis aries
-

Synonyms

Synonyms Comment Organism
11beta-HSD2
-
Ovis aries
11beta-hydroxysteroid dehydrogenase isoforms 2
-
Ovis aries

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Ovis aries

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
assay at Ovis aries

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005
-
pH 8.4, 37°C Ovis aries 11beta-hydroxyprogesterone
0.00012
-
pH 8.4, 37°C Ovis aries 11beta-hydroxy-allopregnanolone
0.00015
-
pH 8.4, 37°C Ovis aries 5alpha-dihydrocorticosterone
0.00026
-
pH 8.4, 37°C Ovis aries 3alpha,5alpha-tetrahydrocorticosterone
0.00035
-
pH 8.4, 37°C Ovis aries 11beta-hydroxytestosterone
0.0004
-
pH 8.4, 37°C Ovis aries 11-oxo-progesterone
0.00047
-
pH 8.4, 37°C Ovis aries 11-dehydrocortisterone
0.0005
-
pH 8.4, 37°C Ovis aries 3alpha,5alpha-tetrahydroaldosterone
0.0008
-
pH 8.4, 37°C Ovis aries 3alpha,5alpha-tetrahydro-dehydrocortisterone
0.00135
-
pH 8.4, 37°C Ovis aries 11-oxo-testosterone
0.0015
-
pH 8.4, 37°C Ovis aries 11-oxo-allopregnanolone
0.0045
-
pH 8.4, 37°C Ovis aries 11beta-hydroxyandrostanediol
0.0078
-
pH 8.4, 37°C Ovis aries 11beta-hydroxyandrostenedione
0.008
-
pH 8.4, 37°C Ovis aries 3alpha,5alpha-tetrahydrocortisol
0.008
-
pH 8.4, 37°C Ovis aries 11-oxo-3beta,5alpha-tetrathydrotestosterone