Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-deoxycorticosterone | IC50: 0.001 mM | Ovis aries aries | |
4-pregnen-11,17-diol-3,20-dione | IC50: 0.00035 mM | Ovis aries aries | |
4-pregnen-11alpha-ol-3,20-dione | IC50: 0.0001 mM | Ovis aries aries | |
4-pregnen-11beta-ol-3,20-dione | IC50: 0.00005 mM | Ovis aries aries | |
4-pregnen-16alpha-ol-3,20-dione | not inhibitory | Ovis aries aries | |
4-pregnen-17,21-diol-3,20-dione | not inhibitory | Ovis aries aries | |
4-pregnen-17alpha,20alpha-diol-3-one | not inhibitory | Ovis aries aries | |
4-pregnen-17alpha-ol-3,20-dione | IC50: 0.047 mM | Ovis aries aries | |
4-pregnen-20alpha-ol-3-one | IC50: 0.007 mM | Ovis aries aries | |
4-pregnen-20beta-ol-3-one | IC50: 0.008 mM | Ovis aries aries | |
4-pregnen-21-ol-3,20-dione | IC50: 0.001 mM | Ovis aries aries | |
4-pregnen-3,11,20-trione | IC50: 0.0004 mM | Ovis aries aries | |
4-pregnen-3,20-dione | IC50: 0.0011 mM | Ovis aries aries | |
5-pregnen-3beta,11beta-diol-20-one | IC50: 0.0001 mM | Ovis aries aries | |
5alpha-pregnan-11alpha-ol-3,20-dione | IC50: 0.00035 mM | Ovis aries aries | |
5alpha-pregnan-11beta,17alpha,21-triol-3,20-dione | IC50: 0.0031 mM | Ovis aries aries | |
5alpha-pregnan-11beta,21-diol-3,20-dione | IC50: 0.00015 mM | Ovis aries aries | |
5alpha-pregnan-3alpha,11beta,17alpha,21-tetrol-20-one | IC50: 0.008 mM | Ovis aries aries | |
5alpha-pregnan-3alpha,11beta,21-triol-20-one | IC50: 0.00026 mM | Ovis aries aries | |
5alpha-pregnan-3alpha,11beta-diol-20-one | IC50: 0.00012 mM | Ovis aries aries | |
5alpha-pregnan-3alpha,17alpha,21-triol-11,20-dione | IC50: 0.0055 mM | Ovis aries aries | |
5alpha-pregnan-3alpha,21-diol-11,20-dione | IC50: 0.0008 mM | Ovis aries aries | |
5alpha-Pregnan-3alpha,21-diol-20-one | IC50: 0.0024 mM | Ovis aries aries | |
5alpha-pregnan-3alpha-ol-20-one | IC50: 0.008 mM | Ovis aries aries | |
5beta-pregnan-3alpha,11alpha-diol-20-one | not inhibitory | Ovis aries aries | |
5beta-pregnan-3alpha,11beta,17alpha,21-tetrol-20-one | not inhibitory | Ovis aries aries | |
5beta-pregnan-3alpha,11beta,21-triol-20-one | not inhibitory | Ovis aries aries | |
5beta-pregnan-3alpha,11beta-diol-20-one | not inhibitory | Ovis aries aries | |
5beta-Pregnan-3alpha,21-diol-20-one | not inhibitory | Ovis aries aries | |
5beta-Pregnan-3alpha-ol-20-one | not inhibitory | Ovis aries aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000014 | - |
11beta,21-dihydroxypregn-4-en-3,20-dione | isoform 11beta-HSD2 | Ovis aries aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | Ovis aries aries | isoform 11beta-HSD2 | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+ | - |
r | |
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | Ovis aries aries | i.e. corticosterone | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries aries | - |
sheep, isoform 11beta-HSD2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Ovis aries aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | isoform 11beta-HSD2 | Ovis aries aries | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+ | - |
r | |
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ | i.e. corticosterone | Ovis aries aries | 21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD | NAD-specific 11beta-HSD isoform type 2 | Ovis aries aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | isoform 11beta-HSD2 | Ovis aries aries | |
NADH | isoform 11beta-HSD2 | Ovis aries aries |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
IC50: 0.00005 mM | Ovis aries aries | 4-pregnen-11beta-ol-3,20-dione | |
0.0001 | - |
IC50: 0.0001 mM | Ovis aries aries | 4-pregnen-11alpha-ol-3,20-dione | |
0.0001 | - |
IC50: 0.0001 mM | Ovis aries aries | 5-pregnen-3beta,11beta-diol-20-one | |
0.00012 | - |
IC50: 0.00012 mM | Ovis aries aries | 5alpha-pregnan-3alpha,11beta-diol-20-one | |
0.00015 | - |
IC50: 0.00015 mM | Ovis aries aries | 5alpha-pregnan-11beta,21-diol-3,20-dione | |
0.00026 | - |
IC50: 0.00026 mM | Ovis aries aries | 5alpha-pregnan-3alpha,11beta,21-triol-20-one | |
0.00035 | - |
IC50: 0.00035 mM | Ovis aries aries | 4-pregnen-11,17-diol-3,20-dione | |
0.00035 | - |
IC50: 0.00035 mM | Ovis aries aries | 5alpha-pregnan-11alpha-ol-3,20-dione | |
0.0004 | - |
IC50: 0.0004 mM | Ovis aries aries | 4-pregnen-3,11,20-trione | |
0.0008 | - |
IC50: 0.0008 mM | Ovis aries aries | 5alpha-pregnan-3alpha,21-diol-11,20-dione | |
0.001 | - |
IC50: 0.001 mM | Ovis aries aries | 11-deoxycorticosterone | |
0.001 | - |
IC50: 0.001 mM | Ovis aries aries | 4-pregnen-21-ol-3,20-dione | |
0.0011 | - |
IC50: 0.0011 mM | Ovis aries aries | 4-pregnen-3,20-dione | |
0.0024 | - |
IC50: 0.0024 mM | Ovis aries aries | 5alpha-Pregnan-3alpha,21-diol-20-one | |
0.0031 | - |
IC50: 0.0031 mM | Ovis aries aries | 5alpha-pregnan-11beta,17alpha,21-triol-3,20-dione | |
0.0055 | - |
IC50: 0.0055 mM | Ovis aries aries | 5alpha-pregnan-3alpha,17alpha,21-triol-11,20-dione | |
0.007 | - |
IC50: 0.007 mM | Ovis aries aries | 4-pregnen-20alpha-ol-3-one | |
0.008 | - |
IC50: 0.008 mM | Ovis aries aries | 5alpha-pregnan-3alpha-ol-20-one | |
0.008 | - |
IC50: 0.008 mM | Ovis aries aries | 4-pregnen-20beta-ol-3-one | |
0.008 | - |
IC50: 0.008 mM | Ovis aries aries | 5alpha-pregnan-3alpha,11beta,17alpha,21-tetrol-20-one | |
0.047 | - |
IC50: 0.047 mM | Ovis aries aries | 4-pregnen-17alpha-ol-3,20-dione |