Application | Comment | Organism |
---|---|---|
molecular biology | results demonstrate that the promoter activity of the human PHGDH gene is positively regulated by the action of transcription factors Sp1 and NF-Y | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | sequence analysis of the PHGDH promoter region exhibits several putative transcription factor binding sites for NF-Y, Sp1, GATA-1, p53, AP2, and AP1, with no TATA-box motif at an appropriate position. Transfection of a series of deletion constructs of the promoter region into HeLa cells reveals that the core positive promoter activity resides in the -276 to +1, which contains two GC-motifs for binding Sp1 and one CCAAT-motif for NF-Y. Mutational analysis and electrophoretic mobility shift assay indicates that both the proximal GC-motif and CCAAT-motif are crucial for full induction of the promoter activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
3-phosphoglycerate dehydrogenase | - |
Homo sapiens |
PGDH | - |
Homo sapiens |