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Literature summary for 1.1.1.9 extracted from

  • Granstroem, T.B.; Izumori, K.; Leisola, M.
    A rare sugar xylitol. Part I: The biochemistry and biosynthesis of xylitol (2007), Appl. Microbiol. Biotechnol., 74, 277-281.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Candida sp. HA 167

Inhibitors

Inhibitors Comment Organism Structure
D-xylulose
-
Candida sp. HA 167

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.039
-
xylitol
-
Candida sp. HA 167

Organism

Organism UniProt Comment Textmining
Candida sp. HA 167
-
-
-

Reaction

Reaction Comment Organism Reaction ID
xylitol + NAD+ = D-xylulose + NADH + H+ it is concluded that the enzyme reaction follows the mechanism where coenzyme binds first and leaves last. Therefore, dissociation of D-xylulose-NADH complex is suggested to be the rate-limiting step Candida sp. HA 167

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xylitol + NAD+
-
Candida sp. HA 167 D-xylulose + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
XDH
-
Candida sp. HA 167
xylitol dehydrogenase
-
Candida sp. HA 167

Cofactor

Cofactor Comment Organism Structure
NADH
-
Candida sp. HA 167

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
10
-
D-xylulose
-
Candida sp. HA 167