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Literature summary for 1.1.1.87 extracted from

  • Yamamoto, T.; Eguchi, T.
    Thiahomoisocitrate: a highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway (2008), Bioorg. Med. Chem., 16, 3372-3376.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid
-
Saccharomyces cerevisiae
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
Saccharomyces cerevisiae
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
-
Saccharomyces cerevisiae
trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
homoisocitrate
-
Saccharomyces cerevisiae
0.02
-
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
Saccharomyces cerevisiae
0.15
-
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
homoisocitrate + NAD+
-
Saccharomyces cerevisiae alpha-ketoadipate + NADH + CO2
-
r
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate + NAD+
-
Saccharomyces cerevisiae ? + NADH + CO2
-
?
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate + NAD+
-
Saccharomyces cerevisiae ? + NADH + CO2
-
?

Synonyms

Synonyms Comment Organism
homoisocitrate dehydrogenase
-
Saccharomyces cerevisiae
ScHICDH
-
Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.59
-
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
Saccharomyces cerevisiae
2
-
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
-
Saccharomyces cerevisiae
17
-
homoisocitrate
-
Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000097
-
trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate
-
Saccharomyces cerevisiae
0.01
-
trisodium (2S,3R)-2-(carboxylatomethoxy)-3-hydroxybutanedioate
-
Saccharomyces cerevisiae
12
-
3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid
-
Saccharomyces cerevisiae